Side Effects of Starting Zoloft Again

Make name: Zoloft®

Tablets: 25 mg, fifty mg, 100 mg
Liquid: 20 mg/mL

Generic name: sertraline (SER tra leen)

All FDA black box warnings are at the end of this fact sheet. Delight review before taking this medication.

What Is Sertraline And What Does Information technology Treat?

Sertraline is an antidepressant medication that works in the brain. It is approved for the handling of major depressive disorder (MDD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder, and social anxiety disorder. It is also canonical to treat obsessive-compulsive disorder (OCD) in adults, children and adolescents anile 6-17 years.

Symptoms of depression include:

Depressed mood - feeling sad, empty, or tearful
Feeling worthless, guilty, hopeless, and helpless
Loss of interest or pleasance in your usual activities
Sleep and swallow more than or less than usual (for most people it is less)
Low energy, trouble concentrating, or thoughts of death (suicidal thinking)
Psychomotor agitation ('nervous energy')
Psychomotor retardation (feeling like you are moving and thinking in slow motion)
Suicidal thoughts or behaviors

PTSD occurs when a person experiences a traumatic event (e.g., attack, combat experience) and then later feels on edge; avoids situations that remind them of the upshot; and experiences flashbacks or nightmares.

PMDD is a condition where a woman experiences depression, tension, and irritability for a few days prior to menstruation that end when menstruation begins. These symptoms are more than severe than those of premenstrual syndrome (PMS).

Panic Disorder occurs when a person experiences unexpected and repeated episodes of intense fear. These episodes have physical symptoms including breast pain, shortness of breath, heart palpitations, sweating, dizziness, and nausea. Fear of hereafter episodes is besides function of panic disorder.

Obsessive Compulsive Disorder (OCD) occurs when a person experiences the post-obit symptoms at the same fourth dimension:

Obsessions (unwanted, recurrent, and agonizing thoughts)
Compulsions (repetitive, ritualized behaviors that the person feels driven to perform in gild to lessen the anxiety produced by the obsessions)

Social phobia/social anxiety disorder is a fright of situations where one may experience as if they are existence judged by others. Symptoms include:

Blushing
Difficulty talking
Nausea
Sweating
Shaking

Sertraline may besides be helpful when prescribed "off-label" for binge-eating disorder, bulimia nervosa, and generalized feet disorder (GAD). "Off-label" means that it hasn't been approved by the Food and Drug Assistants for this condition. Your mental wellness provider should justify his or her thinking in recommending any "off-label" handling. They should be clear about the limits of the research effectually that medication and if there are any other options.

What Is The Most Important Information I Should Know About Sertraline?

Exercise not stop taking sertraline, even when y'all feel amend. With input from you lot, your health care provider will assess how long y'all will need to take the medicine.

Missing doses of sertraline may increase your run a risk for relapse in your symptoms.

Stopping sertraline abruptly may result in ane or more of the post-obit withdrawal symptoms: irritability, nausea, feeling silly, vomiting, nightmares, headache, and/or paresthesias (prickling, tingling sensation on the skin).

Depression is also a part of bipolar disease. People with bipolar disorder who have antidepressants may be at adventure for "switching" from depression into mania. Symptoms of mania include "high" or irritable mood, very high cocky-esteem, decreased need for sleep, pressure to keep talking, racing thoughts, existence easily distracted, frequently involved in activities with a large risk for bad consequences (for example, excessive buying sprees).

Medical attention should be sought if serotonin syndrome is suspected. Please refer to serious side effects for signs/symptoms.

Are There Specific Concerns Most Sertraline And Pregnancy?

If you are planning on becoming pregnant, notify your wellness intendance provider to all-time manage your medications. People living with MDD who wish to get pregnant confront of import decisions. Untreated MDD has risks to the fetus, as well equally the female parent. Information technology is important to discuss the risks and benefits of treatment with your doctor and caregivers. For women who have antidepressant medications during weeks 13 through the end of their pregnancy (second and third trimesters), at that place is a chance that the baby can be born earlier it is fully developed (earlier 37 weeks).

For mothers who have taken SSRIs during their pregnancy, at that place appears to be less than a one% run a risk of infants developing persistent pulmonary hypertension. This is a potentially fatal condition that is associated with use of the antidepressant in the second half of pregnancy. However, women who discontinued antidepressant therapy were 5 times more probable to take a depression relapse than those who continued their antidepressant. If you are pregnant, delight discuss the risks and benefits of antidepressant use with your health care provider.

Circumspection is advised with breastfeeding since sertraline does laissez passer into breast milk.

What Should I Hash out With My Health Intendance Provider Before Taking Sertraline?

Symptoms of your condition that bother you the well-nigh
If yous have thoughts of suicide or harming yourself
Medications you have taken in the by for your status, whether they were effective or acquired any adverse furnishings
If y'all feel side effects from your medications, talk over them with your provider. Some side effects may pass with fourth dimension, but others may require changes in the medication.
Whatsoever other psychiatric or medical bug you have, including a history of bipolar disorder
All other medications you are currently taking (including over the counter products, herbal and nutritional supplements) and whatsoever medication allergies y'all have
Other not-medication treatment you are receiving, such equally talk therapy or substance abuse treatment. Your provider can explain how these unlike treatments work with the medication.
If y'all are significant, programme to become pregnant, or are breastfeeding
If you drink alcohol or use drugs

How Should I Take Sertraline?

Sertraline is usually taken one time per twenty-four hour period with or without nutrient.

Typically patients begin at a low dose of medicine and the dose is increased slowly over several weeks.

The dose usually ranges from fifty mg to 200 mg. Only your health care provider can decide the correct dose for you.

If you are taking it for PMDD, sertraline can be taken once daily (everyday) or intermittently (normally starting 14 days prior to period through the first full twenty-four hour period of period of each bicycle).

The liquid should be measured with an oral syringe or dropper which y'all can get from your pharmacy. Information technology should be added to 4 ounces of h2o, ginger ale, lemon/lime soda, lemonade, or orange juice immediately prior to taking the medication. It should not be mixed in advance.

Consider using a calendar, pillbox, alarm clock, or cell phone alert to help you remember to take your medication. You may also enquire a family member or friend to remind you or bank check in with you to be sure you are taking your medication.

What Happens If I Miss A Dose Of Sertraline?

If you lot miss a dose of sertraline, take it as soon as you recall, unless information technology is closer to the time of your next dose. Discuss this with your health care provider. Do not double your adjacent dose or take more than what is prescribed.

What Should I Avert While Taking Sertraline?

Avoid drinking alcohol or using illegal drugs while you lot are taking antidepressant medications. They may subtract the benefits (e.g., worsen your condition) and increase adverse effects (e.grand., sedation) of the medication.

What Happens If I Overdose With Sertraline?

If an overdose occurs, call your doctor or 911. You lot may demand urgent medical care. You lot may as well contact the poison control center at one-800-222-1222.

A specific handling to reverse the furnishings of sertraline does non exist.

What Are The Possible Side Effects Of Sertraline?

Common side effects

Headache, nausea, diarrhea, dry oral fissure, increased sweating
Feeling nervous, restless, fatigued, sleepy or having problem sleeping (indisposition)

These will oft better over the first week or ii as yous continue to take the medication.

Sexual side effects, such as problems with orgasm or ejaculatory delay oftentimes exercise not diminish over time.

Rare/serious side effects

Low sodium blood levels (symptoms of low sodium levels may include headache, weakness, difficulty concentrating and remembering), teeth grinding, angle closure glaucoma (symptoms of angle closure glaucoma may include eye pain, changes in vision, swelling or redness in or around middle).

Serotonin syndrome (symptoms may include shivering, diarrhea, confusion, severe musculus tightness, fever, seizures, and death), seizure

SSRI antidepressants including sertraline may increase the chance of bleeding events. Combined use of aspirin, nonsteroidal anti-inflammatory drugs (due east.g., ibuprofen, naproxen), warfarin, and other anti-coagulants may increase this hazard. This may include gums that bleed more easily, nose drain, or gastrointestinal bleeding. Some cases have been life threatening.

Are In that location Any Risks For Taking Sertraline For Long Periods Of Time?

To engagement, in that location are no known problems associated with long term apply of sertraline. It is a safe and effective medication when used as directed.

What Other Medications May Interact With Sertraline?

Sertraline should not exist taken with or within two weeks of taking monoamine oxidase inhibitors (MAOIs). These include phenelzine (Nardil®), tranylcypromine (Parnate®), isocarboxazid (Marplan®), rasagiline (Azilect®), and selegiline (Emsam®).

Although rare, at that place is an increased risk of serotonin syndrome when sertraline is used with other medications that increase serotonin, such as other antidepressants, migraine medications chosen "triptans" (e.yard., Imitrex®), some pain medications (eastward.g., tramadol (Ultram®)), and the antibody linezolid (Zyvox®).

Sertraline should not be taken with pimozide (Orap®).

Sertraline may increment the effects of other medications that can cause haemorrhage (due east.thou., ibuprofen (Advil®, Motrin®), warfarin (Coumadin®) and aspirin).

Sertraline liquid should Non be taken in combination with disulfiram (Antabuse®) due to the alcohol content of the concentrate.

How Long Does It Have For Sertraline To Work?

Sleep, free energy, or appetite may show some improvement inside the offset i-2 weeks. Improvement in these concrete symptoms can be an important early on point that the medication is working. Depressed mood and lack of involvement in activities may demand up to 6-8 weeks to fully improve.

Summary of FDA Blackness Box Warnings

Suicidal thoughts or actions in children and adults

Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients with major depressive disorder (MDD), both developed and pediatric, may feel worsening of their depression and/or the emergence of suicidal ideation and beliefs (suicidality) or unusual changes in beliefs, whether or non they are taking antidepressant medications. This take a chance may persist until significant remission occurs.

In brusque-term studies, antidepressants increased the risk of suicidality in children, adolescents, and immature adults when compared to placebo. Brusk-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults across age 24. Adults age 65 and older taking antidepressants have a decreased risk of suicidality. Patients, their families, and caregivers should be alert to the emergence of feet, restlessness, irritability, aggressiveness and insomnia. If these symptoms emerge, they should be reported to the patient's prescriber or health care professional. All patients being treated with antidepressants for whatsoever indication should sentry for and notify their wellness care provider for worsening symptoms, suicidality and unusual changes in beliefs, especially during the starting time few months of treatment.

Provided by

(December 2020)

©2020 The College of Psychiatric and Neurologic Pharmacists (CPNP) and the National Alliance on Mental Illness (NAMI). CPNP and NAMI brand this document available nether the Creative Commons Attribution-No Derivatives four.0 International License. Final Updated: January 2016.

This information is being provided as a community outreach effort of the College of Psychiatric and Neurologic Pharmacists. This data is for educational and informational purposes only and is not medical advice. This data contains a summary of important points and is not an exhaustive review of information nigh the medication. Ever seek the advice of a physician or other qualified medical professional person with any questions you may take regarding medications or medical weather. Never delay seeking professional medical advice or disregard medical professional advice as a outcome of any information provided herein. The College of Psychiatric and Neurologic Pharmacists disclaims any and all liability declared as a effect of the data provided herein.

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